Validation of a modified QuEChERS method for the extraction of multiple classes of pharmaceuticals from soils

Chemical and Biological Technologies in Agriculture

Table 4 Parameters used to validate the method

CEC	r²	LOD (µg kg⁻¹)	LOQ (µg kg⁻¹)	Level of fortification
				50 µg L⁻¹		100 µg L⁻¹		500 µg L⁻¹
				R%	RSD	R%	RSD	R%	RSD
Gemfibrozil	0.9993	12.7	25.4	92.8	3.0	84.7	1.5	93.4	4.1
Clarithromycin	0.9993	12.6	25.3	79.8	3.4	80.8	4.3	87.7	3.1
Metoprolol	0.9982	15.3	30.6	85.6	3.2	83.2	2.9	86.1	2.8
Fluconazole	0.9993	10.8	21.6	92.7	6.2	86.3	7.5	95.0	6.7
Diclofenac	0.9982	18.4	36.9	89.0	11.8	82.7	11.8	94.1	6.7
Climbazole	0.9967	15.6	31.3	79.5	1.9	83.2	2.3	88.4	1.8
Carbamazepine	0.9984	10.0	20.0	93.9	1.3	93.1	1.2	99.1	11.4

LOD limit of detection, LOQ limit of quantification, R recovery percentage, RSD relative standard deviation