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Table 2 Metabolites differentially accumulated in M10 culture filtrates cultivated in different media (MM, MM + Fe, YPD, PDB, 1/10 PDB) and under different conditions (dark + shaking, light + shaking, dark + static, light + static)

From: Induced secondary metabolites of the beneficial fungus Trichoderma harzianum M10 through OSMAC approach

Compound

Regulation

PDB vs MM

PDB vs MM + Fe

PDB vs YPD

PDB vs 1/10 PDB

Dark + shaking

 T39butenolide

↑

↑

↑

↓

 Harzianolide

↓

↓

↑

↓

Light + shaking

 Dehydro harzianolide

↓

↓

↓

↓

 5-hydroxy-2,3-dimethyl-7-methoxychromone

↑

↑

↑

↑

 Harzianolide

↓

↓

↓

↓

 Harzianic acid

↓

↑

↓

↓

 Ferricrocin

↓

↓

↓

↓

Dark + static

 Dehydro harzianolide

↑

↑

↑

↑

 Harzianolide

↑

↑

↑

↑

 Isoharzianic acid

↑

↑

↑

↓

 Harzianic acid

↑

↑

↑

↓

Light + static

 Dehydro harzianolide

↑

↓

↑

↓

 T39butenolide

↓

↓

↓

↓

 Dimethyl-harzianic acid

↑

↑

↑

↓

 Isoharzianic acid

↑

↑

↑

↓

 Harzianic acid

↑

↑

↑

↓

 Homoharzianic acid

↓

↓

↓

↓

 Coprogen B

↓

↓

↓

↓

  1. ↓ = down-regulated, PDB vs other media; ↑ is up-regulated, PDB vs other media