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Table 4 Antimicrobial activity and MIC of standard pure compounds as components of C. sativa

From: Identification and antimicrobial activity of most representative secondary metabolites from different plant species

Bacteria THC CBD CBD/THC
ZoI (mm)a MIC (mg L−1) ZoI (mm)a MIC (mg L−1) ZoI (mm)a MIC (mg L−1)
Gram+
 Bacillus cereus (A1I) 8.5 ± 1.2A > 60 12.0 ± 1.0B > 60 14.5 ± 1.4C > 60
 Bacillus thuringiensis (B7I2) 9.5 ± 1.3A > 60 13.0 ± 1.1B > 60 14.5 ± 1.3C > 60
 Bacillus amyloliquefaciens (A5TI) 8.0 ± 0.8A > 60 11.0 ± 0.9B > 60 15.0 ± 1.3C > 60
Gram−
 Pseudomonas orientalis (A14-1II) NI NI NI
 Stenotrophomonas maltophilia (B9TIII) NI NI NI
  1. Assays were performed in triplicate and results are the mean of three values ± standard deviation
  2. NI no inhibition zone was observed, THC Δ9-tetrahydrocannabinol, CBD cannabidiol
  3. Different letters in superscript to numerical data indicate significant differences (p value < 0.05)
  4. aZoI: diameter of inhibition zone obtained after 24 h of incubation in agar well diffusion assays. ZoI < 10 mm: low
  5. antimicrobial activity; 11 < ZoI < 15 mm: middle antimicrobial activity; ZoI > 16 mm: high antimicrobial activity