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Table 4 Comparative minimum inhibitory concentration (MIC/MBC) of the peptide and essential oils with some antibiotic suggested according to the Clinical and Laboratory Standards Institute (CLSI)

From: Antimicrobial activity of some plant essential oils and an antimicrobial-peptide against some clinically isolated pathogens

Bacterial strainsAntimicrobial Activity MIC/MBC (µg/mL)
cLFchimera GentamicinVitex agnus-castusCuminum cyminumMentha piperitaSalvia officinalisMIC
Gram-positive
 Staphylococcus aureus14.2 ± 0.3/28.4 ± 0.3*62.5 ± 4.0/125.0 ± 8.0125.0 ± 13.0/250.0 ± 23.0125.0 ± 16.0/250.0 ± 25.062.5 ± 10.0/125.0 ± 18.00.12–1
Gram-negative
 Klebsiella pneumoniaeND/ND250.0 ± 11.0/500.0 ± 13.0500.0 ± 33.0/500.0 ± 35.0250.0 ± 17.0/250.0 ± 23.0250.0 ± 18.0/500.0 ± 32.0ND
 Salmonella typhimurium3.5 ± 0.1/28.4 ± 0.4125.0 ± 11.0/250.0 ± 16.0500.0 ± 27.0/500.0 ± 28.0250.0 ± 25.0/250.0 ± 17.0500.0 ± 36.0/500.0 ± 21.0 ≥ 16
 Pseudomonas aeruginosa9.7 ± 0.3/39.0 ± 0.9500.0 ± 23.0/ND500.0 ± 35.0/ND500.0 ± 36.0/ND250.0 ± 24.0/500.0 ± 28.00.5–2
 Salmonella enteritidis7.0 ± 0.5/28.4 ± 0.8500.0 ± 24.0/500.0 ± 19.0500.0 ± 26.0/500.0 ± 30.0250.0 ± 19.0/250.0 ± 21.0125.0 ± 17.0/250.0 ± 24.0 ≥ 16
 Escherichia coli9.7 ± 0.1/19.5 ± 0.6250.0 ± 17.0/500.0 ± 30.0125.0 ± 15.0/250.0 ± 19.0500.0 ± 35.0/NDND/ND0.25–1
 Escherichia coli 015739 ± 0.5.0/39 ± 1.0125.0 ± 11.0/250.0 ± 18.0125.0 ± 16.0/250.0 ± 21.0500.0 ± 20.0/500.0 ± 20.0500.0 ± 37.0/ND0.25–1
  1. Values are results of four replicates. Data are collected as MICs according to the CLSI. ND not determined
  2. *Data are mean ± SD (standard deviation)
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