Table 4 Comparative minimum inhibitory concentration (MIC/MBC) of the peptide and essential oils with some antibiotic suggested according to the Clinical and Laboratory Standards Institute (CLSI)
Bacterial strains | Antimicrobial Activity MIC/MBC (µg/mL) | |||||
|---|---|---|---|---|---|---|
cLFchimera Gentamicin | Vitex agnus-castus | Cuminum cyminum | Mentha piperita | Salvia officinalis | MIC | |
Gram-positive | ||||||
 Staphylococcus aureus | 14.2 ± 0.3/28.4 ± 0.3* | 62.5 ± 4.0/125.0 ± 8.0 | 125.0 ± 13.0/250.0 ± 23.0 | 125.0 ± 16.0/250.0 ± 25.0 | 62.5 ± 10.0/125.0 ± 18.0 | 0.12–1 |
Gram-negative | ||||||
 Klebsiella pneumoniae | ND/ND | 250.0 ± 11.0/500.0 ± 13.0 | 500.0 ± 33.0/500.0 ± 35.0 | 250.0 ± 17.0/250.0 ± 23.0 | 250.0 ± 18.0/500.0 ± 32.0 | ND |
 Salmonella typhimurium | 3.5 ± 0.1/28.4 ± 0.4 | 125.0 ± 11.0/250.0 ± 16.0 | 500.0 ± 27.0/500.0 ± 28.0 | 250.0 ± 25.0/250.0 ± 17.0 | 500.0 ± 36.0/500.0 ± 21.0 |  ≥ 16 |
 Pseudomonas aeruginosa | 9.7 ± 0.3/39.0 ± 0.9 | 500.0 ± 23.0/ND | 500.0 ± 35.0/ND | 500.0 ± 36.0/ND | 250.0 ± 24.0/500.0 ± 28.0 | 0.5–2 |
 Salmonella enteritidis | 7.0 ± 0.5/28.4 ± 0.8 | 500.0 ± 24.0/500.0 ± 19.0 | 500.0 ± 26.0/500.0 ± 30.0 | 250.0 ± 19.0/250.0 ± 21.0 | 125.0 ± 17.0/250.0 ± 24.0 |  ≥ 16 |
 Escherichia coli | 9.7 ± 0.1/19.5 ± 0.6 | 250.0 ± 17.0/500.0 ± 30.0 | 125.0 ± 15.0/250.0 ± 19.0 | 500.0 ± 35.0/ND | ND/ND | 0.25–1 |
 Escherichia coli 0157 | 39 ± 0.5.0/39 ± 1.0 | 125.0 ± 11.0/250.0 ± 18.0 | 125.0 ± 16.0/250.0 ± 21.0 | 500.0 ± 20.0/500.0 ± 20.0 | 500.0 ± 37.0/ND | 0.25–1 |