Fig. 9

Response curve fitting diagram of amino acids and their derivatives in the aminoacyl-tRNA biosynthesis under different nicotine concentrations (A); response curve fitting diagram of organic acids in glyoxylate and dicarboxylate metabolism under different nicotine concentrations (B); response curve fitting diagram of nucleotides and their derivatives in biosynthesis of alkaloids derived from histidine and purine, pyrimidine metabolism under different nicotine concentrations (C); the associated expression of amino acids and their derivatives, nucleotides and their derivatives, organic acids, red box means positive correlation, green box means negative correlation (* represents significance p < 0.05, ** represents significance p < 0.01, *** represents significance p < 0.001, based on Pearson correlation test) (D)