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Table 3 Comparison of direct infusion and hyphenated techniques in mass spectrometry

From: Metabolomics applied in bioenergy

MS strategy Advantages Disadvantages
Direct-infusion MS - Simple sample preparation - Not recommended for complex matrix
- No pre-separation steps - Ion suppression effect
- Fast analysis - Complex mass spectra
- Low solvent consumption  
- High-throughput screening tool  
- Most used for qualitative analysis  
Chromatography coupled to MS - Better accuracy and sensitivity for the analysis of complex mixtures - Pre-separation steps depending on chemical composition of samples
- Less ion suppression effect - Longer time required for analysis
- Most used for quantitative analysis - Wastes large amount of solvents