Table 3 Comparison of direct infusion and hyphenated techniques in mass spectrometry
MS strategy | Advantages | Disadvantages |
|---|---|---|
Direct-infusion MS | - Simple sample preparation | - Not recommended for complex matrix |
- No pre-separation steps | - Ion suppression effect | |
- Fast analysis | - Complex mass spectra | |
- Low solvent consumption | Â | |
- High-throughput screening tool | Â | |
- Most used for qualitative analysis | Â | |
Chromatography coupled to MS | - Better accuracy and sensitivity for the analysis of complex mixtures | - Pre-separation steps depending on chemical composition of samples |
- Less ion suppression effect | - Longer time required for analysis | |
- Most used for quantitative analysis | - Wastes large amount of solvents |